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News and Events


Announcements:

April 2025

New Hire:
MCIF is excited to welcome Kirsten Martin, PhD! Kirsten joined MCIF from Lawrence Berkeley National Labs where she was a Senior Scientific Engineering associate in the group of Dr. Rebecca Abergel. Kirsten received her Ph.D. from Stony Brook University performing radiometal-chelator research in Eszter Boros' group.

October 2024

New Hire:
MCIF is proud to welcome Michael Montano, B.S. to the group! Michael comes to MCIF from Dana-Farber's radiation safety office, bringing a depth of knowledge in radioactive material handling and safety.

June 2024

Award:
Congratulations Stephen Dragotakes for being awarded the Society of Nuclear Medicine and Molecular Imaging's Sally W. Schwarz Award for Outstanding Contribution in Radiopharmacy!

June 2023

Award:
Congratulations Stephen Dragotakes for being awarded the Society of Nuclear Medicine and Molecular Imaging's Presidential Distinguished Service Award!

April 2023

New Hire:
MCIF is proud to welcome Dr. Erik Jimmy Jakobsson, PhD! Jimmy recently completed post-doctoral research at both the National Institutes of Health and subsequently at Washington University, Mallinckrodt Institute of Radiology in St. Louis, Missouri.

January 2023

New Hire:
MCIF welcomes Lead Technician Anamae Azzopardi, MSc, to the team! Anamae bring previous experience in radiopharmaceutical GMP manufacturing and quality control.

August 2022

New Hire:
MCIF is proud to welcome Dr. Hyunjung Kim to the team! Dr. Kim recently completed her post-doctoral studies at University of California San Francisco in the lab of Dr. Michael Evans, and Samsung Medical Center in the lab of Dr. Yearn Seong Choe.

April 2022

Patent Granted:
A Compact Multi-Isotope Solid Target System Utilizing Liquid Retrieval. US Patent, 11,310,902 B2, Granted April 19, 2022

April 2021

New Hire:
MCIF is excited to welcome Dr. Shin Hye (Grace) Ahn to the team! Dr. Ahn recently completed her post-doctoral studies at Stony Brook University in the lab of Dr. Eszter Boros.

January 2020

Research Grant Awarded:
SNMMI 2020 Mitzi & William Blahd, MD, Pilot Research Grant "Development of a PET radiotracer for imaging KRAS G12C in NSCLS" Mark Dornan, Ph.D.

June 2020

Promotion:
Anthony Belanger, Ph.D. promoted to Scientific Director, Lead Scientist in MCIF

October 2019

Research Grant Awarded:
DFCI Friends of DFCI 2020 Award "The first in vivo-evaluation of BRAF PET imaging"  Mark Dornan, Ph.D.

Publications & Presentations:

June 2025
Presentation:
“Pre-clinical development of next-generation FAP-targeting radioligands with improved tumor retention” To be presented by Kyle Novakowski at the 2025 SNMMI annual meeting, New Orleans, LA (June 2025).
May 2025
Publication:
“Radiosynthesis and in vivo evaluation of [18F]BEAN as a potential mitochondria-based PET biomarker for metabolic disorders,” Kaittanis, C.; Kim, H.; Teceno, T.; Petibon, Y.; Knight, A.; Crouthamel, M.; Belanger, A. P.; Xiong, Z.; Ruangsiriluk, W.; Modi, M.; Islam, R.; Natarajan, M.; Papaioannou, N.; Winkelmann, C. T.; Tauscher, J.; McQuade, P. Bioorg Med Chem Lett. 2025, 120:130142. doi: 10.1016/j.bmcl.2025.130142. Epub 2025 Feb 14. PMID: 39956274.
November 2024
Publication:
“Longitudinal imaging of therapeutic enzyme expression after gene therapy for Fabry disease using Positron Emission Tomography and the radiotracer [18F]AGAL,” Kaittanis, C.; Teceno, T.; Knight, A.; Petibon, Y.; Sandoval, P.; Cohen, L.; Ahn, S. H.; Clark, L.; Nguyen, Q. D.; Belanger, A.; Ruangsiriluk, W.; Mukherji, S.; Constantinescu, C.; Amenta, A. L.; Narayanan, S.; Deshpande, M.; Islam, R.; Yuan, S.; McQuade, P.; Winkelmann, C. T.; Lohith, T. G. Molecular Therapy. 2025, 33 (1), https://doi.org/10.1016/j.ymthe.2024.11.021
July 2024
Publication:
“[18F]F-AraG imaging reveals association between neuroinflammation and brown- and bone marrow adipose tissue,” Levi, J.; Guglielmetti, C.; Henrich, T.J.; Yoon, J. C.;Gokhale, P. C.; Reardon, D. A.; Packiasamy, J.; Hyunh, L.;Cabrera, H.;Ruzevich, M.; Blecha, J.; Peluso, M. J.; Huynh, T. L.; An, S. M.; Dornan, M.; Belanger, A. P.; Nguyen, Q. D.; Seo, Y.; Song, H.; Chaumeil, M. M.; VanBrocklin, H. F.; Chae, H. D. Communications Biology. 2024, 7, 793.
May 2024
Presentation:
“Preclinical characterization of 177Lu- and 225Ac-PNT6555 in multiple syngeneic murine tumor models,” Takashima, M; Kwon, O.; Vito, A.; Hallett, R.; Rodriguez, D.; Ahn, S. H.; Belanger, A.; Kumari, R.; Clark, P. A.; Chen, T.; Bednarz, B.; Morris, Z. Presented by Alyssa Vito at the American Radium Society Meeting 2024, Palm Spring, CA (May 2024).
January 2024
Publication:
“Automated radiolabeling and handling of 177Lu- and 225Ac-PSMA-617 using a robotic pipettor,” Ahn, S. H.; Belanger, A. P. Journal of Labelled Compounds and Radiopharmaceuticals. 2024, https://doi.org/10.1002/jlcr.4085
Publication:
“Preclinical development of PNT6555, a boronic acid-based, FAP-targeted radiotheranostic for imaging and treatment of FAP-positive tumors,” Poplawski, S. E.; Hallett, R. H.; Dornan, M. H.; Novakowski, K. E.; Pan, S.; Belanger, A. P.; Nguyen, Q. D.; Wu, W.; Liu, Y.; Ahn, S. H.; Hergott, V. S.; Jones, B.; Lai, J. H.; McCann, J. A. B.; Bachovchin, W. W. Journal of Nuclear Medicine. 2024, 65 (1) 100-108.
October 2023
Publication:
“Radiosynthesis and Early Evaluation of a Positron Emission Tomography Imaging Probe [18F]AGAL Targeting Alpha-Galactosidase A Enzyme for Fabry Disease,” Lohith, T. G.; Kaittanis, C.; Belanger, A. P.; Ahn, S. H.; Sandoval, P.; Cohen, L.; Rajarshi, G.; Ruangsiriluk, W.; Islam, R.; Winkelmann, C.; McQuade, P. Molecules. 2023, 28(20), 7144.

June 2023

Presentation:
“Preclinical application of novel isotopes and combination therapy with the FAP-targeted ligand PNT6555,” Novakowski, K. E; Ahn, S. H.; Dornan, M. H.; Belanger, A. P.; Poplawski, S. E.; Bachovchin, W. W.; Hallett, R. M. Presented by Kyle Novakowski at the Society of Nuclear Medicine and Molecular Imaging 2023 Annual Meeting, Chicago, Il (June 2023)

May 2023

Presentation:
“Method development for centralized clinical production of 177Lu-PSMA-I&T,” Dornan, M. H.; Southcott, L.; Ahn, S. H.; Belanger, A. P.; Hergott, V. S.; McCann, J. A. B. Presented by Lily Southcott at the International Society of Radiopharmaceutical Sciences 2023 Biannual Meeting, Honolulu, HI (May 2023)

April 2023

Publication:
“Landscape of prostate-specific membrane antigen heterogeneity and regulation in AR-positive and AR-negative metastatic prostate cancer,” Bakht M, Yamada Y, Ku SY, Venkadakrishnan VB, Korsen J, Kalidindi TM, Mizuno K, Ahn SH, Seo JH, Garcia MM, Khani F, Elemento O, Long H, Chaglassian A, Pillarsetty NVK, Lewis J, Freedman M, Belanger AP, Nguyen QD, Beltran H. Nature Cancer, 2023, 4, 699-715.

October 2022

Presentation:
“Development and characterization of a next-generation 225Ac-PSMA radioligand,” Vito A, Dornan M, Beale T, Felten A, Ernste M, Nguyen Q, Ahn S, Belanger AP, Pan S, Wu W, Liu Y, Lai JH, Bachovchin WW, Hergott V, McCann J, Hallett R. European Association of Nuclear Medicine 2022 Annual Meeting, Barcelona, Spain, (October 2022)

September 2022

Presentation:
“18F-Fluciclovine Delineates PSMA-Suppressed Castration Resistant Prostate Cancer,” Bakht M, Yamada Y, Ku SY, Venkadakrishnan VB, Korsen J, Kalidindi TM, Mizuno K, Ahn SH, Seo JH, Garcia MM, Khani F, Elemento O, Long H, Freedman M, Chaglassian A, Belanger AP, Nguyen QD, Pillarsetty NVK, Lewis J, Beltran H. World Molecular Imaging Congress 2022 annual meeting, Miami, FL (September 2022)

June 2022

Presentation:
“Pre-clinical characterization of the novel Fibroblast Activation Protein (FAP) targeting ligand PNT6555 for the imaging and therapy of cancer,” Hallett RM, Poplawski SE, Novakowski KE, Dornan MH, Ahn SH, Pan S, Wengen W, Yuxin L, Sanford DG, Hergott VS, Nguyen QD, Belanger AP, Lai JH, Bachovchin WW, McCann JAB. Society of Nuclear Medicine and Molecular Imaging 2022 annual meeting, Vancouver, Canada (June 2022)

April 2022

Presentation:
“Pre-clinical characterization of the novel Fibroblast Activation Protein (FAP) targeting ligand PNT6555 for the imaging and therapy of cancer,” Hallett RM, Poplawski SE, Novakowski KE, Dornan MH, Ahn SH, Pan S, Wengen W, Yuxin L, Sanford DG, Hergott VS, Nguyen QD, Belanger AP, Lai JH, Bachovchin WW, McCann JAB. American Association of Cancer Research 2022 annual meeting, New Orleans, LA., (April 2022)

August 2020

Publication:
​Synthesis of a 11C-Isotopologue of the B-Raf-Selective Inhibitor Encorafenib Using In-Loop [11C]CO2 Fixation.
Dornan MH, Petrenyov D, Simard JM, Boudjemeline M, Mititelu R, DaSilva JN, Belanger AP.
ACS Omega. 2020 Aug 16;5(33):20960-20966.

August 2018

Oral Presentation:
"
Galileo- An automated synthesis module for development and manufacturing of novel radio-metallic tracers." Bars E. 17th Workshop on Targetry and Target Chemistry. Coimbra, Portugal.

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